Batman and Nightwing are forced to team with the Joker's sometimes-girlfriend Harley Quinn to stop a global threat brought about by Poison Ivy and Jason Woodrue, the Floronic Man.
When Mr. Freeze, desperate to save his dying wife, kidnaps Barbara Gordon (Batgirl) as an involuntary organ donor, Batman and Robin must find her before the operation can begin.
Batman discovers a mysterious teen-aged girl with super-human powers and a connection to Superman. When the girl comes to the attention of Darkseid, the evil overlord of Apokolips, events take a decidedly dangerous turn.
Batman works desperately to find a bomb planted by the Joker while Amanda Waller hires her newly formed Suicide Squad to break into Arkham Asylum to recover vital information stolen by the Riddler.